Telik, Inc.

Terrapin Technologies, Inc.

Anna Voronova

Dorit Ron

Lawrence M Kauvar

John W Patterson

Hugo O Villar

Eugene W Napolitano

Nicki Vasquez

Gene Napolitano

Compounds having immunomodulating activity are identified using a methodology which employs TER14687, TER10311 and/or TER17210 as standards. The effect candidate compounds have on PKC-theta interaction with cognate binding proteins is measured and compared with the standards. The interaction can be measured by a variety of techniques, including assessing translocation of said PKC-theta or fragment. Kits containing the TER14687, TER10311 and/or TER17210 standards are disclosed. TER14687, TER10311 and/or TER17210 are useful in modulating the immune system in a subject by reducing T-cell activity. TER14687, TER10311, TER17210 are used as leads to develop other compounds having immunomodulating activity.

Methods to identify immunomodulators using cognate interaction of

The present invention discloses that the fyn protein binds to the PKC-theta protein. Based on this observation, the present invention provides methods of identifying agents which can be used to modulate immune system activity by blocking fyn/PKC-theta binding and therapeutic methods using such agents.

Methods for identifying agents which block the interaction of fyn with

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Wayland, MA, United States of America

Anna Voronova