Egyt Gyogyszervegyeszeti Gyar

Mta Kozponti Kemial Kutato Intezete

Biocal Cyogyszergvar

Mta Kozponti Kemiai Kutato Intezete and Biogal Gyogyszergyar

Anna Szabolcs Nee Borbas

Janos Sagi

Attila Szemzo

Laszlo Tvos

Sandor Jancso

Gyorgy Bacsa

Istvan Csernus

Helga Tudos Nee Feuer

Katalin Marossy

Eva Medgyesi Nee Lukacs

Zsuzsa Veres

Miklos Vajda

Istvan Szinai

Istvan Horvath

Janos Nagy

Csilla Rethati

Istvan Koczka

Pal Ivan

Ildiko Fritzsche Nee Lukacs

Maria Peredy Nee Kajtar

A method of treating herpes eye infections with an ophthalmic composition comprising 5-propyl-2'-deoxyuridine.

Method of treating herpes eye infections with 5-propyl-2'-deoxyuridine

The invention relates to an externally applicable, antiviral pharmaceutical composition accumulating in the skin for treating herpes infections, which composition comprises 0.2-5% by mass of 5-isopropyl-2'-.beta.-deoxyuridine admixed with carriers, diluents and/or other additives conventionally used in the production of pharmaceutical compositions for external use.

Topical process for treating herpes infections using 5-isopropyl-2'-.beta.-

The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, ##STR1## wherein R.sup.1 stands for a hydrogen atom, C.sub.1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C.sub.1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, ##STR2## wherein R is identical with R.sup.1, except where R.sup.1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V ##STR3## and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.

Process for the preparation of 5-(2-bromovinyl)-uridine

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Budapest, Hungary

Anna Szabolcs Nee Borbas