Antibe Therapeutics Inc.

Ctg Pharma S.r.l.

Anna Sparatore

Giuseppe Cirino

John L Wallace

Stefano Fiorucci

Piero Del Soldato

Giuseppe Caliendo

Vincenzo Santagada

Vicenzo Santagada

The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

Derivatives of 4- or 5-aminosalicylic acid

The present invention provides L-arginine salts of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these L-arginine salts of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of an inflammatory condition of the GI tract such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).

Salts of 4- or 5-aminosalicylic acid

Growing community of inventors

Milan, Italy

Anna Sparatore