Saint Louis University

Anna Smith

Rajeev Aurora

Angel Baldan

Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (Tc). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (Tc) through introduction of a low-dose of a RANK agonist such as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.

Pulsed introduction of low-dose RANKL as a therapy for diet-induced atherosclerosis

Systems and methods for inhibiting atherosclerosis using FoxP3+ CD8 T-cells (Tc). Osteoclasts are induced to produce FoxP3+ CD8 T-cells (Tc) through introduction of a low-dose of a RANK agonist suck as RANKL. The RANKL was found to best work when provided in accordance with a schedule resulting in a pulsed administration.

Growing community of inventors

St. Peters, MO, United States of America

Anna Smith