Alligator Bioscience Ab

Aptevo Research and Development LLC

Aptevo Reserch and Development LLC

Anna Sall

Christina Furebring

Peter Ellmark

Laura Von Schantz

Sara Fritzell

Laura Varas

Lynda Misher

Gabriela Hernandez-Hoyos

David Bienvenue

Danielle Mitchell

Niina Veitonmaki

Jessica Petersson

Karin Enell Smith

Danielle Van Citters

The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods

The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with binding specificity for domain 2 of human CD137 which are capable of inhibiting the binding of a reference antibody to human CD137. The antibodies and fragments have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.

Anti-CD137 antibodies and uses thereof

Oncofetal antigen binding proteins and related compositions and methods

Growing community of inventors

Lund, Sweden

Anna Sall