Acucela Inc.

University of Washington

Phaserx, Inc.

Genevant Sciences Gmbh

Other

Anna S Gall

Mark W Orme

Ian L Scott

Vladimir Aleksandrovich Kuksa

Feng Hong

Thomas Little

Jennifer Lynn Gage

Allan Sachs Hoffman

Patrick S Stayton

Thomas L Little, Jr

Paul Hickok Johnson

Charbel Diab

Priyadarsi De

Mary Gallagher Prieve

Craig L Duvall

Anthony Convertine

Robert W Overell

Danielle Benoit

Amber E E Paschal

Ryo Kubota

Qin Jiang

Lana Michele Rossiter

Kevin F McGee, Jr

Anthony J Convertine

Paul Johnson

Sean D Monahan

Michael S DeClue

Vladimir Aleksandrovich Kuska

Richard Daifuku

Dmitri S Sergueev

Amber E Paschal

Amber Ee Paschal

Paul H Johnson

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Alkoxy compounds for disease treatment

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.

Micellic assemblies

The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

Styrenyl derivative compounds for treating ophthalmic diseases and disorders

Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.

Diblock copolymers and polynucleotide complexes thereof for delivery into cells

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.

The present invention provides fluorinated 5-aza-2'-deoxycytidine compounds, such as 2&#x2032;,2&#x2032;-difluoro-5-aza-2&#x2032;-deoxycytidine, compositions that include the compounds, methods for making the compounds, and methods for inhibiting DNA methyltransferase, treating solid tumors, and treating hematologic cancers by administering the compounds.

Fluorinated pyrimidine analogs and methods of use thereof

Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders

Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.

Multiblock copolymers

Growing community of inventors

Woodinville, WA, United States of America

Anna S Gall