Uniwersytet Jagiellonski

Warszawski Uniwersytet Medyczny

Anna Rapacz

Gniewomir Latacz

Szczepan Mogilski

Michal Abram

Krzysztof Kaminski

Marcin Jakubiec

Marta Struga

Bartlomiej Szulczyk

2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2-oxopyrrolidin-1-yl)propanamide derivatives with R-configuration at the stereogenic center are disclosed, showing broad-spectrum protective activity in animal models of epileptic seizures, pain, depression and anxiety that are simultaneously devoid of undesirable sedative effects. Additionally, the disclosed derivatives have neuroprotective effects in the in vitro and in vivo studies.

Modified amino acid derivatives for the treatment of neurological diseases and selected psychiatric disorders

The first object of the invention is the compound of general formula (I) or pharmaceutically acceptable salts thereof. A second object of the invention is the use of compounds described by general formula (I) as active ingredient in pharmaceutical compositions for the treatment of epileptic seizures or neuropathic pain or migraine.

(2,5-dioxopyrrolidin-1-yl)(phenyl)-acetamide derivatives and their use in the treatment of neurological diseases

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Cracow, Poland

Anna Rapacz