Yale University

University of Rhode Island

Anna Moshnikova

Donald M Engelman

Yana K Reshetnyak

Oleg A Andreev

John Deacon

The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.

pHLIP®-mediated intracellular delivery of immuno-stimulatory compounds

The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIPconstruct comprising an antibody recruiting molecule linked to one or more pHLIPpeptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.

pH-triggered membrane peptide-mediated epitope tethering at cell surfaces

The invention features a composition comprising a potent cytotoxic compound and a pH low insertion peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. The pH low insertion peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.

pH low insertion peptide targeted delivery of potent cytotoxic compounds

The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP&#xae;).

Growing community of inventors

Warwick, RI, United States of America

Anna Moshnikova