Serina Therapeutics, Inc.

Anna Mero

Michael David Bentley

J Milton Harris

Zhihao Fang

Tacey Viegas

Kunsang Yoon

Francesco Maria Veronese

The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.

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Padua, Italy

Anna Mero