Yale University

Anna Marie Pyle

Akiko Iwasaki

Michael C Van Zandt

Andrew Kohlway

Dahai Luo

Tianyang Mao

David Rawling

Lin Yuan

Olga Fedorova

Erik Gunnar Jagdmann

Albert DeBerardinis

Erik Jagdmann

Chen Zhao

Xiaodong Jiang

The present invention provides compositions and methods for inhibiting group II intron splicing for treating or preventing a disease or disorder associated with an organism harboring an active group II intron. The present invention also provides compositions and methods for inhibiting group II intron splicing for inhibiting, preventing or reducing growth of an organism harboring an active group II intron.

Compositions and methods for inhibiting group II intron RNA

The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5′ triphosphate or a 5′ diphosphate.

Interferon production using short RNA duplexes

The present disclosure provides small hairpin nucleic acid molecules capable of stimulating interferon production. The nucleic acid molecules of the present disclosure has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises at least one 5'-triphosphate and/or at least one 5&#x2032;-diphosphate. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection, and/or ameliorating, minimizing, reversing, and/or preventing persistent SARS-CoV-2 viral infection, and/or minimizing or preventing SARS-CoV-2 viral infection-derived mortality and/or lethality, in a subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in a tumor-bearing subject. In certain embodiments, compounds and/or compositions of the disclosure are useful for treating, ameliorating, and/or preventing SARS-CoV-2 viral infection in an immune-compromised and/or immunodeficient subject.

Compositions and methods for treating SARS-CoV-2 infection

The present invention provides compositions, methods, and kits related to reverse transcriptases derived from E.r. maturase.

Reverse transcriptase and methods of use

Methods for treating SARS-CoV-2 infection

The present invention provides a small hairpin nucleic acid molecule that is capable of stimulating interferon production. The nucleic acid molecule of the present invention has a double-stranded section of less than 19 base pairs and at least one blunt end. In certain embodiments, the molecule comprises a 5' triphosphate or a 5&#x2032; diphosphate.

Growing community of inventors

Guilford, CT, United States of America

Anna Marie Pyle