Dsm IP Assets B.v.

Bayer Cropscience Ag

Dsm N.v.

Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Anna Maria Cornelia Francisca Castelijns

Andreas Hendrikus Maria De Vries

Albert Schnatterer

Frank Volz

Ben De Lange

Quirinus B Broxterman

Daniel Mink

Gerhard Steinbauer

Johannes Gerardus De Vries

Stefaan Marie Andre De Wildeman

Bernardus Kaptein

Martina Kotthaus

Henricus Martinus Maria Gerardus Straatman

Michele Catherine Christianne Janssen

Dominique Monique Charles Callant

Michèle Catherine Christianne Janssen

Rinke Marcel Altink

Jeroen Antonius Franciscus Boogers

Klaus Edegger

Andreas Hendrikus Maria Vries De

Henricus Wilhemus Leonardus Marie Vaessen

Quirinus Bernardus Broxterman

De Ben Lange

Henricus Wilhelmus Leonardus Marie Vaessen

Gerardus Karel Maria Verzijl

De Johannes Gerardus Vries

Petrus Johannes Hermsen

The present invention relates to a process for the preparation of diaminobutane from ornithine, comprising steps of: i. preparing a solution of (a) a salt of ornithine and an acid; and (b) an aldehyde or a ketone, or a mixture thereof; in (c) a solvent, wherein the solvent comprises a protic organic solvent or a dipolar aprotic organic solvent, or a mixture thereof and ii. heating the solution to a temperature above 100&#xb0; C., thereby inducing decarboxylation of the ornithine and formation of diaminobutane.

Process for the preparation of diaminobutane

This invention relates to a process for the preparation of alkenoic acid esters comprising contacting a lactone with an alcohol and an acidic catalyst in the gas phase, characterized in that the process is carried out in the presence of at least 0.26 wt. % water, relative to the amount of the lactone. The process may result in a good production yield and selectivity with respect to the production of alkenoic acid esters and may also result in less formation of dialkylethers. The improved yield advantageously allows energy conservation.

Process to produce alkenoic acid esters from lactones

This invention relates to a process for the preparation of alkenoic acid esters comprising contacting a lactone with an alcohol and an acidic heterogeneous catalyst, characterized in that the process is carried out in the presence of at least 20 ppm of an acid having a pKa of 5 or less, relative to the amount of the lactone. The presence of at least 20 ppm of an acid having a pKa of 5 or less may stabilize the catalyst during the reaction and may also be used for reactivating an acidic heterogeneous catalyst. The improved yield advantageously allows energy conservation.

The present invention relates to a novel process for the preparation of cis-1-ammonium-4-alkoxycyclohexanecarbonitrile salts and to novel intermediates or starting compounds which are passed through or used in the process according to the invention.

Process for the preparation of cis-1-ammonium-4-alkoxycyclohexanecarbonitrile salts

The invention provides a process for the preparation of valerolactone, said process comprising reacting levulinic acid with hydrogen by using a solid Ru catalyst, characterized in that the process is carried out in the presence of at least 0.08% (w/w) water relative to the amount of levulinic acid. Said process may be faster and more selective. This process advantageously allows the production of valerolactone from renewable sources. The valerolactone may be used in the preparation of methylpentenoate, adipic acid dimethylester, adipic acid, hexamethylenediamine, and polyamide 6,6 (all claimed).

Process to produce valerolactone from levulinic acid

Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with Rbeing a branched Calkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10). 

Convergent synthesis of renin inhibitors and intermediates useful therein

This invention relates to novel alpha-substituted &#x3b1;,&#x3b2;-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula (I) in which Rand Rmay be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and Rand Rmay be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and Rmay be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals. 

Alpha-substituted &#x3b1;,&#x3b2;-unsaturated E- or Z-aldehydes, use thereof, and processes for their preparation &#x3b1;,&#x3b2;

Process for the preparation of (schiff bases of) &agr;-alkyl-&agr;-amino acid amides

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Echt, Netherlands

Anna Maria Cornelia Francisca Castelijns