The University of British Columbia

Qlt Phototherapeutics, Inc.

Qlt Inc.

Other

Quadra Logic Technologies, Inc.

Qlt, Inc. and

Ciba Vision Opthalmics

Qlt Phototherapeutices Inc.

Novartis Ag

Anna M Richter

Julia G Levy

David H Dolphin

Ethan D Sternberg

David W Hunt

Guillermo O Simkin

Ronald Erwin Boch

David W C Hunt

Elizabeth M Waterfield

Agnes How-Ching Chan

Modestus O Obochi

Ashok Jain

Andrew Norman Tovey

William C Stewart

Gustav Huber

Jack Rootman

Mario G Fsadni

Gustave Huber

Peter Lutwyche

Claude A A Hariton

Marcello Nick Bussanich

David R Mallek

Danielle Wenkstern

Howard E Meadows

John Robert North

David Wc Hunt

Philippe Maria Clotaire Margaron

Modestus O K Obochi

Beth Anne Allison

Simon Leong

P Haydn Pritchard

Jean-Marie Houle

Patrick Mark Curry

Philippe Maria Margaron

Claude A Hariton

Ethan Sternberg

Mario Fsadni

Nick Bussanich

Claude Aa Hariton

Jain Ashok

Andrew N Tovey

This invention relates generally to the field of pharmacotherapeutics and the use of photodynamic therapy ('PDT'). In particular, the invention provides a method for reducing or preventing the effects of inflammation arising from normal dose photodynamic therapy (PDT), which method comprises exposing a target tissue in a subject that has been treated with normal dose PDT treatment to low dose light having a wavelength absorbed by a photosensitizing agent used in said normal dose PDT treatment for a time sufficient to reduce or prevent the effects of inflammation arising from said normal dose PDT treatment. The method is particularly useful in reducing or preventing the effects of inflammation arising from normal dose PDT treatment of ocular tissues.

Method for reducing or preventing PDT related inflammation

Immuno-adjuvant photodynamic therapy to treat and prevent metastatic cancer is effected using photosensitizers in combination with immuno-adjuvants to destroy metastatic tumor cells.

Immuno-adjuvant PDT treatment of metastatic tumors

Photodynamic therapy (PDT) is used to stimulate and/or restore hair growth in areas of hair loss. Methods and compositions relating to PDT treatment for alopecia are disclosed. In light of PDT use to remove unwanted hair by inactivating or destroying hair follicles or destroying the tissue feeding the hair follicles, such methods and compositions relate to a surprising and unexpected discovery. PDT permits a means to treat conditions relating to hair loss such as androgenic alopecia, alopecia areata and drug-induced alopecia.

Photodynamic therapy for the treatment of hair loss

New compounds useful in photodynamic therapy are of the formula and their 1,4-diene isomersand the metallated and/or labeled and/or conjugated forms thereof

Ethylene glycol esters as photoactive agents

Methods, compositions and articles for reducing or preventing the effects of inflammation

Photodynamic therapy to prevent secondary cataracts is effected using photosensitizers such as green porphyrins as photoactive agents to destroy remnant lens epithelial cells.

Use of photodynamic therapy for prevention of secondary cataracts

New compounds useful in photodynamic therapy are of the formula ##STR1## and their 1,4-diene isomers and the metallated and/or labeled and/or conjugated forms thereof

The invention provides a method to inhibit the formation of neovasculature while maintaining viability of the underlying tissue by subjecting a subject in which angiogenesis is to be inhibited to sublethal photodynamic therapy. The invention also provides a model for assessing sublethal PDT protocols to inhibit angiogenesis in particular target tissues.

Model and method for angiogenesis inhibition

Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.

Green porphyrins as immunomodulators

Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen, as well as to interfere with intercellular communication. These effects occur in the absence of radiation absorbed by the green porphyrin.

Growing community of inventors

Vancouver, Canada

Anna M Richter