Perkinelmer Health Sciences, Inc.

Revvity Health Sciences, Inc.

Anna M Potier

Jordan Haddock

Joseph D Trometer

Stephanie Dallaire

Cristina Gutierrez-Mateo

Provided are processes for the use of a single dried blood sample for the preparation of test samples including targets of differing structures. The processes allow the same dried blood sample to be used for preparation of a first test sample including a non-nucleic acid target, and the same dried blood sample to be subsequently processed for preparation of a test sample that includes a nucleic acid target whereby the processes preserve the ability of the nucleic acid to be detected in subsequent detection assays following prior isolation of non-nucleic acid targets.

Methods for sequentially preparing different test samples from a single dried blood sample

Processes are provided that include additive compounds suitable for detecting the activity of an enzyme such as a lysosomal storage enzyme where the additive is a salt of oleic acid. Inclusion of a salt of oleic acid unexpectedly improves enzyme activity and reproducibility.

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Waltham, MA, United States of America

Anna M Potier