The Brigham and Women's Hospital, Inc.

University of California

Anna M Krichevsky

Santosh Kesari

Brit Mollenhauer

Nadiya Teplyuk

Howard L Weiner

Erik J Uhlmann

Eugene Ponomarev

Tatyana Veremeyko

Rachid El-Fatimy

A method of treating a subject who has a glioma, e.g., astrocytoma, oligodendroglioma, or glioblastoma multiforme tumor, the method comprising administering to the subject a therapeutically effective amount of a Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) microRNA-10b (miR-10b) editing complex comprising a CRISPR Associated Protein 9 (Cas9) and at least one guide RNA targeting a sequence encoding miR-10b.

Genome editing for treating glioblastoma

The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.

Diagnosing and monitoring CNS malignancies using microRNA

Methods for treating a neurodegenerative disorder associated with aggregation of tau protein in the brain of a subject, comprising administering to the subject a therapeutically effective amount of one or more inhibitory nucleic acids targeting microRNA-26a, microRNA-26b, or both microRNA-26a and 26b.

Targeting microRNA-26a/b for the treatment of neurodegenerative disease

Diagnosing and monitoring CNS malignancies using MicroRNA

Methods of treating, reducing the risk of developing, or delaying the onset of an inflammatory disease are disclosed. The methods involved providing a subject with or at risk of developing an inflammatory disease and administering to the subject an effective amount of a first therapeutic composition comprising miR-124. Further provided are methods of diagnosing a subject with or at risk of developing an inflammatory disease.

Treatment of inflammatory diseases using miR-124

Growing community of inventors

Brookline, MA, United States of America

Anna M Krichevsky