Auburn University

Edward Via College of Osteopathic Medicine—auburn

Anna M Cochran

Alexandre M Samoylov

Tatiana I Samoylova

Kenny V Brock

Valery A Petrenko

Nancy R Cox

James W Gillespie

Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.

Phage-peptide constructs for stimulating an immune response against CD47

Disclosed are methods, compositions, zona pellucida binding peptides and polypeptides, and expression vectors for use in species-specific immunocontraception of animals, which include landscape bacteriophage. The disclosed compositions may include immunogenic compositions or vaccines.

Phage constructs, sequences and antigenic compositions for immunocontraception of animals

Growing community of inventors

Auburn, AL, United States of America

Anna M Cochran