Farmitalia Carlo Erba S.p.a.

Anna M Caravaggi

Sergio Mantegani

Germano Bosisio

Aldemio Temperilli

Giuliana Arcari

Patricia Salvati

Enrico Di Salle

Osvaldo Sapini

Guiliana Arcari

Novel ergoline derivatives formed by reaction of an 8-carboxy ergoline with a carbodiimide and having hypotensive and antiprolatinic activity.

Dimethylaminoalkyl-3-(ergoline-8'.beta.carbonyl)-ureas

Compounds and process for making same are disclosed, the compounds having the formula (I): ##STR1## wherein R.sub.1 represents methyl, phenyl, piperidino, 1-pyrrolidinyl, morpholino or 4-methyl-1-piperazinyl, alkyl or alkoxy having from 1 to 4 carbon atoms, amino, substituted amino of the formula NHR' (wherein R' is alkyl having from 1 to 4 carbon atoms, cycloalkyl, a benzyl, or phenyl) or substituted amino of the formula NR' R'' (wherein R' and R'' both represent alkyl having from 1 to 4 carbon atoms);

Ergot derivatives

A compound is disclosed of the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, or a carboxy, alkoxycarbonyl, piperidinocarbonyl, 1-pyrrolidinylcarbonyl, morpholinocarbonyl, carbamoyl or benzylcarbamoyl group, or an alkylcarbamoyl or dialkylcarbamoyl group in which the, or each, alkyl group has from 1 to 4 carbon atoms;

Tetracyclic indole derivatives

Compounds and process for making same are disclosed, the compounds having the formula (I): ##STR1## wherein R.sub.1 represents a methyl, phenyl, piperidino, 1-pyrrolidinyl, morpholino or 4-methyl-1-piperazinyl group, an alkyl or alkoxy group having from 1 to 4 carbon atoms, an amino group, a substituted amino group of the formula NHR' (wherein R' represents an alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group, a benzyl group, or a phenyl group) or a substituted amino group of the formula NR' R'' (wherein R' and R'' both represent alkyl groups having from 1 to 4 carbon atoms);

Growing community of inventors

Milan, Italy

Anna M Caravaggi