The General Hospital Corporation

Canthera Therapeutics Inc.

Massachusetts Institute of Technology

Harvard College

The Brigham and Women's Hospital, Inc.

Massachusetts General Hospital Corporation

Anna I Mandinova

Sam W Lee

Victor A Neel

Michael Andrew Foley

Peter J Elliott

Robert J Gould

Robert Samuel Langer

George M Church

Carlo Giovanni Traverso

Carl Magnus Schoellhammer

Noah Davidsohn

Denitsa M Milanova

A method for the systemic delivery of a polypeptide within a subject is provided by creating genetically modified skin cells via topical introduction of a genetically engineered virus which delivers a nucleic acid encoding a therapeutic polypeptide for expression by the skin cells, wherein the expressed therapeutic polypeptide is secreted by the skin cells and is introduced into the circulatory system of the subject.

Systemic delivery of polypeptides

Provided herein are methods and assays for isolating and culturing seborrheic keratosis cells ex vivo. Also provided herein are screening assays using cultured seborrheic keratosis cells and methods for treating seborrheic keratosis in a subject.

Agents and methods for treating and preventing seborrheic keratosis

Disclosed herein are assays and methods for distinguishing a keratoacanthoma from squamous cell carcinoma. Methods for diagnosing a keratoacanthoma are also provided. Methods for treating variants of seborrheic keratoses (i.e., keratoacanthoma, acanthosis nigricans, or epidermal nevus) are also provided.

Methods for detecting and treating variants of seborrheic keratoses

This disclosure relates to inhibitors of the Wni pathway, and compositions comprising the same, as well as to their use in the treatment of disorders characterized by the activation of Writ pathway signaling (e.g., cancer), as well as to the modulation of cellular events mediated by VVnt pathway signaling.

Wnt/b-catenin inhibitors and methods of use

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

Compounds and compositions for treating cancer

The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed. A representative compound according to the invention is: 

The invention provides methods for the treatment of cancer in a subject by the administration of myrsinoic acid A and/or one or more myrsinoic acid A analogs.

Growing community of inventors

Newton, MA, United States of America

Anna I Mandinova