Akonni Biosystems, Inc.

Keck Graduate Institute

Other

California Institute of Technology

Claremont Biosolutions LLC

Keck Graduate Institute of Applied Life Sciences

Keck Graduate Insitute

Anna Hickerson

James D Sterling

Ali Nadim

Christopher G Cooney

Bruce D Irvine

Robert Doebler

Reza Miraghaie

Robert W Doebler, Ii

Morteza Gharib

Phil Belgrader

Arash Kheradvar

Ryan P Talbot

Barbara Erwin

Denice Woyski

Phillip Belgrader

Derek Rinderknecht

Angelika Niemz

Kristina Roskos

Hsiang-Wei Lu

Laurence Loumes

Arian Soroush Forouhar

Oscillating angularly rotating a container containing a material may cause the material to be separate. Denser or heavier material may unexpectedly tend to collected relatively close to the axis of rotation, while less dense or light material may tend to collect relatively away from the axis of rotation. Oscillation along an arcuate path provides high lysing efficiency. Alternatively, a micromotor may drive an impeller removably received in a container. Lysing may be implemented in batch mode, flow-through stop or semi-batch mode, or flow-through continuous mode. Lysing particulate material may exceed material to be lysed or lysed material and/or air may be essentially eliminated from a chamber to increase lysing efficiency.

System, apparatus and method for material preparation and/or handling

A disposable and inexpensive biological diagnostic cartridge for the amplification and detection of nucleic acids includes a configuration having a reaction pouch for amplification which is compressed by a flexible pump pouch for detection of the amplified reaction.

System and cartridge for efficient nucleic acid testing

An isothermal reaction and analysis system may include a receiver to receive sample holders, a thermal control subsystem to control a temperature of the receiver, an excitation subsystem, a detection subsystem and an analysis subsystem. Excitation sources and/or detectors are positioned to enhance data collection. Sample holders may include filters, selectively blocking and passing wavelengths or bands of electromagnetic radiation.

Systems and devices for isothermal biochemical reactions and/or analysis

First and second structures are connected by helical fibers. The orientation between the first and second structures are changed, and by doing so, the positions of the helical fibers are correspondingly changed. The position of change of the helical fibers can be used for a pumping effect, or to change some other fluidic characteristics. One other fluidic characteristics, for example, may use the movement of the helical fibers as a valve.

Helically actuated positive-displacement pump and method

A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to receive a temperature-control fluid and comprises a flexible, heat conductive surface that comes in contact with at least a portion of an exterior surface of the reaction chamber after receiving the temperature-control fluid. Also disclosed are a bladder thermal cycler, a temperature-control bladder assembly and methods for producing a thermal cycle in a reaction chamber.

Temperature control device with a flexible temperature control surface

A multilayered impedance pump is formed by an inner tube and an outer tube which have different mechanical characteristics. The outer tube is relatively stiff, and can be used for a structural material. The inner tube is excitable, and a gel is placed between the inner and outer tube. The actuator actuates the gel to cause pressure waves along the inner tube.

Resonant multilayered impedance pump

Growing community of inventors

Altadena, CA, United States of America

Anna Hickerson