Genevant Sciences Gmbh

University of Washington

Phaserx, Inc.

Anna Galperin

Mary Gallagher Prieve

Sean D Monahan

Debashish Roy

Charbel Diab

Pierrot Harvie

Maher Qabar

Michael S DeClue

Amber E Paschal

Russell N Johnson

Michael E Houston, Jr

Michael E Houston

Jeremy Barribeau

Jean-Rene E Ella-Menye

Barry Fulkerson

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Fluid access devices include a machine-side hydraulic circuit and a patient-side hydraulic circuit, and are configurable between a connected state and at least one disconnected state. In the connected state, fluid flows between the machine-side hydraulic circuit and the patient-side hydraulic circuit. In the disconnected state, fluid does not flow between the machine-side hydraulic circuit and the patient-side hydraulic circuit. In some disconnected states, fluid recirculates through at least one of the machine-side hydraulic circuit or the patient-side hydraulic circuit in the disconnected state.

Fluid access devices and methods

Disclosed are branched PEG molecules, including branched PEG-lipids and branched-PEG proteins, as well as related compositions and methods for making branched PEG molecules. Also disclosed are related compositions, systems, and methods for in vivo delivery of therapeutic and diagnostic agents.

Branched peg molecules and related compositions and methods

Nucleic acid constructs and methods of using the same

Growing community of inventors

Seattle, WA, United States of America

Anna Galperin