University of California

Leidos Biomedical Research, Inc.

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Anna E Maciag

Adam Renslo

Joseph Saavedra

Frank McCormick

David Turner

Larry K Keefer

Joseph E Saavedra

Oleg Chertov

Stephan Gysin

Vandana Kumari

Xinhua Ji

Marcin Dyba

Elizabeth D Vo

Lucy M Anderson

Harinath Chakrapani

Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.

K-Ras modulators

Provided herein are the K-Ras inhibitors of the formulae: Also provided are compositions comprising thereof for treating cancer.

Provided herein, inter alia, are methods and compounds of formula (I) for inhibiting K-Ras and for treating cancer. 

Disclosed is a method of treating cancer in a patient comprising administering to the patient an effective amount of a diazeniumdiolated (NO-containing) compound or a pharmaceutically acceptable salt thereof, wherein the cancer cell has an elevated level of reactive oxygen species (ROS) and/or a decreased level of one or more of PRX1, PRX6, and OGG1, compared to a normal cell of the same tissue or tissue type. An example of a diazeniumdiolated compound is Formula (I), wherein X and Q are defined herein. Also disclosed are diazeniumdiolated compounds, pharmaceutical compositions, and methods of use including enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation. 

Diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer

Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein Rand m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation. 

Hybrid diazeniumdiolated compounds, pharmaceutical compositions, and method of treating cancer

Growing community of inventors

Frederick, MD, United States of America

Anna E Maciag