Mcmaster University

Anna Dvorkin-Gheva

Jonathan Lorne Bramson

Christopher W Helsen

Kenneth Anthony Mwawasi

Galina F Denisova

Ksenia Bezverbnaya

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y182T mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

T cell-antigen coupler with Y182T mutation and methods of uses thereof

T cell-antigen coupler with Y182T mutation and methods and uses thereof

A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. The ligand that binds a protein associated with a TCR complex is UCHT1 with a Y177 mutation. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis.

T cell-antigen coupler with Y177 mutation and methods of uses thereof

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Burlington, Canada

Anna Dvorkin-Gheva