Vicuron Pharmaceuticals Inc.

Anna Checchia

Romeo Ciabatti

Gianbattista Panzone

Gianpaolo Candiani

Sonia Maffioli

Gabriella Romano

The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC&#x2014;CO&#x2014;R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH&#x2014; represents deacylated ramoplanin, any of its factors or ramoplanose. The compound of Formula (I) are obtained by reacting a carboxylic acid R&#x2014;COOH with deacylated ramoplanin, any of its factors or ramoplanose protected on the ornitine amino groups. New compounds wherein the hydrocarbon radical R is different form those characaterizing the ramoplanin and ramoplanose natural products and their tetrahydro-derivatives are calimed. The new compounds have the same or better antinfective activity, lower haemolytic effect and better tolerability profile than ramoplanin.

Growing community of inventors

Bovisio Masciago, Italy

Anna Checchia