Magainin Pharmaceuticals, Inc.

Genaera Corporation

Ann Shinnar

Michael A Zasloff

William Alvin Kinney

Meena N Rao

Steven Jones

Mark L Anderson

Jon I Williams

Michael McLane

Thomas Uzzell

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

Treatment of neovascularization disorders with squalimine

A method of inhibiting the proliferation of a wide variety of cells is described. This method includes administering an effective amount of a compound having the following structure: ##STR1## or a pharmaceutically acceptable salt thereof. The proliferation of the following types of cells can be inhibited by this method: lymphocytes, fibroblasts, epithelial cells, smooth muscle cells, and human ovarian cancer cells.

Method of inhibiting proliferation of cells by administering an

Certain aminosterol compounds and pharmaceutical compositions including

Disclosed are aminosterol compounds 1360 and 1361: ##STR1## which can be obtained in isolated or purified form from the liver of the dogfish shark.

Aminosterol compounds and a method of treating infection using the

Aminosterol compounds useful as inhibitors of the sodium/proton

Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also disclosed, including those employing compounds that are inhibitors of a spectrum of NHEs as well as those using compounds that are inhibitors of only one specific NHE. Advantageous screening techniques and assays for evaluating a compound's therapeutic activity are also disclosed.

Method of inhibiting profileration of cells by administering an

A new family of linear antimicrobial peptide from hagfish intestine is described. This invention relates to proteins with antimicrobial properties isolated from hagfish intestine and their corresponding chemical sequences. The antibiotics obtained include, but are not limited to, peptides having a sequence selected from the group consisting of: ##STR1##

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Teaneck, NJ, United States of America

Ann Shinnar