Smithkline Beecham Corporation

Ann Marie Tickner

Ivan Lantos

Robert John Mills

William Morrow Clark

Lendon Norwood Pridgen

Dennis Alan Holt

Mark A Levy

Brian W Metcalf

Conrad John Kowalski

Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (&plus;)(1S, 2R, 3S)-3-&lsqb;2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl&rsqb;-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (&plus;)(1S, 2R, 3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.

process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives

3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives

Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase. Also invented are intermediates used in preparing these compounds.

Steriod 5-alpha-reductase inhibitors

Growing community of inventors

Norristown, PA, United States of America

Ann Marie Tickner