Syntex (u.s.a.) Inc.

Roche Palo Alto LLC

Novartis Ag

F. Hoffmann-La Roche Ag

Ann Marie Madera

Robert James Weikert

Zachary Kevin Sweeney

Jiping Fu

Xianming Jin

Russell Stephen Stabler

Subramanian Karur

Guillaume Lapointe

Matthew C Lucas

Ryan Craig Schoenfeld

Christine E Brotherton-Pleiss

Stephen Matthew Lynch

Clara Jeou Jen Lin

Pravin Iyer

Kerem Erol Ozboya

Stephen M Lynch

This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria. 

Isoxazole hydroxamic acid compounds as LpxC inhibitors

Heteroaryl pyrrolidinyl and piperidinyl ketone derivatives and uses thereof

Compounds of the formula: or pharmaceutically acceptable salts thereof,wherein m, n, Ar, R, R, Rand Rare defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the compounds.

Pyrrolidinyl and piperidinyl ketone derivatives and uses thereof

The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R, R, R, R, p and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

2,4-substituted indoles and methods of use

The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R, R, R, R, and n are those defined herein. The present invention also provides compositions comprising, methods for using, and methods for preparing Compound of Formula I.

2,7-substituted indoles

This invention relates to the (R)-isomers of compounds which are generally muscarinic receptor antagonists and which are represented by Formula I:wherein p, R, R, Rand A are as defined in the specification, or individual isomers, racemic or non-racemic mixtures of isomers, or acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use and preparation as therapeutic drugs.

4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists

Benzocycloalkylenylamine derivatives as muscarinic receptor antagonists

Amino-tetralin derivatives as muscarinic receptor antagonists

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Dublin, CA, United States of America

Ann Marie Madera