Smithkline Beecham Corporation

Ann Marie Eldridge

Johann Hiebl

Robert John Mills

Marvin Sungwhan Yu

Neil Howard Baine

Vance J Novack

Ann Marie Diederich

Processes for preparing N-methyl-L-alanine derivatives and novel intermediates of the process. The derivatives and intermediates are useful for preparing cell-binding agent/maytansinoid complexes.

Process and intermediates

This invention relates to a method for preparing 4-substituted-4-cyanocyclohexane carboxylates by forming the cyclohexane ring by treating a &agr;,&agr;-bis(2-haloethyl)-4-benzeneacetonitrile with a dialkyl malonate and decarboxylating the resulting diester.

Method for preparing cyclohexane carboxylic acids

This invention relates to a process for making certain phenyl urea compounds by using a Lewis acid to effect the ring opening of a benzoxazolinone by an amine.

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Norristown, PA, United States of America

Ann Marie Eldridge