Scandinavian Biopharma Holding Ab

Astra Aktiebolag

Scandinavian Biopharma Holding Ab, C/o Etvax Ab

Gotovax Ab

Ann-Mari Svennerholm

Nils Carlin

Joshua Tobias

Jan Holmgren

Ingrid Bolin

Michael Lebens

An oral vaccine for immunization against ETEC-induced diarrhea, comprising inactivatedcells expressing an ETEC colonization factor antigen and dmLT protein adjuvant, wherein the vaccine preferably comprises less than 10cells per unit dose.

Vaccine for protection against ETEC-induced diarrhea comprising dmLT

A method for increase the presentation of ETEC CS6 antigen on a cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.

Method for increasing ETEC CS6 antigen presentation on cell surface and products obtainable thereof

A method for increasing the presentation of ETEC CS6 antigen on cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETC. Cells and vaccines obtainable by the above methods.

A method for increasing the presentation of ETEC CS6 antigen on cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.

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Västra Frölunda, Sweden

Ann-Mari Svennerholm