Boston Heart Foundation, Inc.

New England Deaconess Hospital Corporation

Ann M Lees

Robert S Lees

Simon W Law

Anibal A Arjona

Mark A Findeis

Ing-Lung Shih

Allan Fischman

Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.

Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis

Vascular disease including asymptomatic atherosclerosis can be diagnosed by administering a synthetic peptide or peptide analog having an affinity for, and propensity to accumulate at, a site of vascular injury to a patient, and then detecting the location of the peptide or peptide analog within the patient's vascular system. The synthetic peptide or peptide analog may include an amino acid sequence sufficiently duplicative of the amino acid sequence of a region of either the apolipoprotein B, apolipoprotein A-I, or elastin proteins such that the peptide or peptide analog accumulates at a site of vascular injury.

Synthetic peptides for arterial imaging

Synthetic peptides for arterial imaging at vascular imaging sites

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Brookline, MA, United States of America

Ann M Lees