Genentech, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Ann L Daugherty

Randall J Mrsny

David J FitzGerald

Thomas W Patapoff

Marian L McKee

Randy J Mrsny

This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to &#x3b1;macroglobulin receptor &#x3b1;2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates of this invention are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection.

Delivery of proteins across polar epithelial cell layers

A compaction assay measuring the viscoelasticity of sputum samples of patients subject to respiratory disease is provided. This assay is useful in determining the therapeutic efficacy of DNase, antibiotic and other respiratory disease treatments in improving lung function.

Compaction assay for assessment of respiratory disease therapy

Polypeptides selected from the group of growth factors and cytokines are administered by intrapulmonary inhalation. Disclosed are novel compositions and devices for effecting the intrapulmonary administration of these polypeptides.

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Palo Alto, CA, United States of America

Ann L Daugherty