Dsm IP Assets B.v.

Nestec S.a.

Ann Fowler

Regina Goralczyk

Goede Schueler

Antoine De Saizieu

Christof Wehrli

Claus Kilpert

Daniel Raederstorff

Ying Wang-Schmidt

Hasan Mohajeri

Karin Wertz

Karin Kuratli

Angelika Friedel

Bernd Mussler

Darko Knutti

Antione De Saizieu

Goede Schuler

Annis Olivia Mayne-Mechan

Joseph Schwager

Goede Schüler

Hydroxytyrosol or olive juice containing hydroxytyrosol in combination with at least one of the compounds selected from the group consisting of: creatine, coenzyme Q10, resveratrol, caffeine, carnitine, B vitamins (B1, B2, B3, B5, B6, and/or B12) and ginseng (preferably: root) extract.can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.

Hydroxytyrosol combinations for enhancing mitochondrial function and energy production

The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein Ris hydrogen or C-alkyl; Ris hydroxy, C-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C-alkyl; Rand Rindependently from each other are hydrogen, hydroxy, hydroxymethyl, C-acyloxy or C-alkoxy; Ris C-alkyl, hydroxymethyl carboxy or methoxycarbonyl; Ris hydrogen, hydroxymethyl, methoxy, oxo or C-acyloxy; Ris hydrogen, or Rand Rtaken together are &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; or Rand Rtaken together are &#x2014;CO&#x2014;O&#x2014;, &#x2014;O&#x2014;CO&#x2014;, &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; Ris hydrogen, or Rand Rtogether to form a bond; Rand Rindependently from each other are C-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C-alkoxycarbonyl with the proviso that at least one of Rand Ris C-alkyl; Rand Rare both hydrogen or Rand Rtogether are oxo, with the further proviso for formula (I) that if Ris hydroxy Ris C-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivatives and their uses

The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein Ris hydrogen or C-alkyl; Ris hydroxy, C-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C-alkyl; Rand Rindependently from each other are hydrogen, hydroxy, hydroxymethyl, C-acyloxy or C-alkoxy; Ris C-alkyl, hydroxymethyl carboxy or methoxycarbonyl; Ris hydrogen, hydroxymethyl, methoxy, oxo or C-acyloxy; Ris hydrogen, or Rand Rtaken together are &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; or Rand Rtaken together are &#x2014;CO&#x2014;O&#x2014;, &#x2014;O&#x2014;CO&#x2014;, &#x2014;CH&#x2014;O&#x2014; or &#x2014;O&#x2014;CH&#x2014;; Ris hydrogen, or Rand Rtogether form a bond; Rand Rindependently from each other are C-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C-alkoxycarbonyl with the proviso that at least one of Rand Ris C-alkyl; Rand Rare both hydrogen or Rand Rtogether are oxo, with the further proviso for formula (I) that if Ris hydroxy Ris C-alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing tricyclic diterpenes and their derivates and their uses

The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.

Dietary and pharmaceutical compositions containing carnosol and/or rosmanol and their uses

The present invention refers to coumarin ethers of the formula (I), wherein Ris H, OH or (E)-3-methyl-but-2-enyl, Ris selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, Ris H, Rand RO together for the group &#x2014;O&#x2014;C(C(&#x2550;CH)CH)H&#x2014;CH&#x2014;O&#x2014; or the group &#x2014;C(H)&#x2550;C(H)&#x2014;C(CH)&#x2014;O&#x2014; or RO and Rtogether form the group &#x2014;O&#x2014;C(H)(C(CH)(H)&#x2014;O&#x2014;C(O)CH)&#x2014;CH&#x2014;, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.

Agents for preventing and treating disorders connected to impaired neurotransmission

The present invention refers especially to 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I) wherein Rand Rare independently from each other C-alkyl, C-alkenyl or x-oxo-C-alkyl with x being an integer from 1 to 6, preferably Rand Rare independently from each other C-alkenyl or y-oxo-C-alkyl with y being an integer from 2 to 5, and wherein Rand Rare independently from each other hydroxy, C-alkyl, C-alkenyl or x-oxo-C-alkyl with x being an integer from 1 to 6, preferably Rand Rare independently from each other hydroxy or y-oxo-C-alkyl with y being an integer from 2 to 5, for use as mood balancing agents and stress relievers, as well as to dietary compositions and fortified food/feed/beverages containing such 3,5-dihydroxy-2,4-cyclohexadienones of the general formula (I), and their uses. 

3,5-dihydroxy-2,4-cyclohexadienones and their derivatives, dietary compositions and fortified food containing them and their uses

Growing community of inventors

Rheinfelden, Switzerland

Ann Fowler