Eli Lilly and Company

Ann Elizabeth Kingston

Barry P Clark

John Richard Harris

 Use of a compound of formula (I) in which, R , R and R are independently hydrogen, (C -C )alkyl, (C -C )alkenyl, C -C )cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted aryl(C -C )alkyl, unsubstituted or substituted aryl(C -C )alkenyl, halo, carboxy, (C -C )alkoxycarbonyl or &mdash;(CH ) &mdash;OH wherein m is 1, 2 or 3; - - - indicates a single or a double bond; X and each independently hydrogen, or X and Y together represent a bridge of the formula &mdash;CH ) &mdash;, where n is 1 or 2; A and A are each independently an unsubstituted or substituted aryl; Z is &mdash;CO&mdash;, &mdash;SO &mdash; or &mdash;CH ; provided that, when Z is &mdash;CO&mdash;, A is not 3,4,5-trimethoxyphenyl; or a pharmaceutically-acceptable salt or ester thereof, for the manufacture of a medicament for the treatment of a condition indicating the administration of a selective mGluR1 antagonist.

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Indianapolis, IN, United States of America

Ann Elizabeth Kingston