Deutsches Krebsforschungszentrum

Ruprecht-karls-universitaet Heidelberg

Ann-Christin Eder

Uwe Haberkorn

Matthias Eder

Klaus Kopka

Martin Schaefer

Ulrike Bauder-Wuest

Martina Benesova

Jens Cardinale

The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x-(B)-x-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer covalently connecting (A) and (B); xis a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein Rto R, R, a, b, Y and Xto Xhave the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Double-labeled probe for molecular imaging and use thereof

The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; xis a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition. 

The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x-(B)-x-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer covalently connecting (A) and (B); xis a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein Rto R, R, a, b, Y and Xto Xhave the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition. 

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Simonswald, Germany

Ann-Christin Eder