Hoffmann-la Roche Inc.

Ann C Sullivan

Richard W Kierstead

Robert W Guthrie

James Guthrie Hamilton

Francis A Mennona

Joseph Triscari

Hugo E Gallo-Torres

Lawrence D Tobias

John Westley

Karen Comai

Perry Rosen

O Neal Miller

The present disclosure relates to the use of thromboxane synthase inhibitors as antiobesity agents and insulin lowering agents. Such compounds fall into a variety of classes among which are 1-substituted imidazoles, 4-substituted imidazoles, 3-substituted pyridines, 3-substituted indoles, 4-substituted pyrimidines, 5-substituted tetrazoles, pyrazolidines, quinazolines, and substituted xanthene carboxylic acids.

Thromboxane synthase inhibitors as insulin lowering agents and

Thromboxane synthase inhibitors as antiobesity agents

The present invention relates to chlorocitric acids of the formula ##STR1## and stereoisomers, optical antipodes and pharmaceutically acceptable salts thereof, to methods of preparation thereof, including intermediates involved therein, and to their use as anorectic agents for the treatment of obesity in mammals.

Chlorocitric acids

Process for making chlorocitric acid

A method is disclosed for the use of polyether ionophores as antiobesity and hypotriglyceridemic agents in warm blooded animals by the administration to an animal in need of such treatment of a therapeutically effective dose of a polyether compound. Also disclosed are examples of such polyether compounds and methods for their preparation.

Polyether ionophores as antiobesity and hypotriglyceridemic agents

The increase of bile flow and the decrease of the levels of lipids such as cholesterol and triglyceride is obtained in biological systems by utilizing specific 3 .alpha.,12.alpha. dihydroxy cholane derivatives and the non-toxic salts of these derivatives.

Method of increasing bile flow and decreasing lipid levels

The compound 5(3,12-dihydroxy-pregnan-20-yl)-pentanoic acid and 7-(3,12-dihydroxy-pregnan-20-yl)-heptanoic acid as well as ester and unsaturated derivatives thereof useful for decreasing the level of lipids such as cholesterol and triglycerides.

Pregnanes

Taurine and glycine derivatives of nor or bisnorcholanic acid or etiocholanic acid which are useful in increasing bile flow or decreasing lipid levels and their method of production from deoxycholic acid, including intermediates thereof.

Taurine and glycine derivatives

Epoxyaconitic acid and esters thereof are useful for the control of lipogenesis.

Growing community of inventors

Cedar Grove, NJ, United States of America

Ann C Sullivan