Council of Scientific and Industrial Research

Department of Biotechnology

Ankur Garg

Suman Preet Singh Khanuja

Ajit Kumar Shasany

Mahendra Pandurang Darokar

Madan Mohan Gupta

Tiruppadiripuliyur Ranganathan Santha Kumar

Sunil Kumar Chattopadhyay

Asish Kumar Bhattacharya

Atul Prakash Kahol

Anil Kumar Gupta

Ram Kishor Verma

Sachin Srivastava

Santosh Kumar Srivastava

Sudeep Tandon

Arvind Singh Negi

Ranganathan Santha Kumar Tirupadiripuliyur

Merajuddin Khan

Anirban Pal

Digvijay Singh

Subhash Chandra Singh

Subash Chandra Verma

Raghvendra Kumar Mishra

Mahendra Pandurang Dardokar

Raghavendra Kumar Mishra

Togarrati Padmapriya

Sunia Kumar Chattopadhyay

Kachin Srivastava

Rajendra Prasad Patel

Tanpreet Kaur

The present invention provides novel loganin analogues and a process for the preparation thereof. The present invention further provides the use of Iridoid glycoside loganin isolated from the fruit pulp of-and its bioactive semi-synthetic analogues against various human cancer cell lines grown in-vitro.

Loganin analogues and a process for the preparation thereof

The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genusby first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40&#xb0; C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50&#xb0; C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

Process for preparing brevifoliol

The present invention relates to the bioactivity of taxanes isolated from the leaves of Himalayan Yew treeagainst human cancer cell lines grown in-vitro and subsequent identification of brevifoliol [1] as anticancer agent useful in the treatment of various types of cancer in humans 

Pharmaceutical composition containing brevifoliol for use in chemotherapeutic treatment of human beings, method therefor

This invention provides a plant growth regulatory activity of a new biologically active synthetic molecule methanone-(3',4&#x2032;,5&#x2032;-trimethoxy) phenyl, 1-naphthyl, 2-O-4&#x2033;-ethyl but-2&#x2033;-enoate. More particularly, the invention relates to the potent plant growth promoting activity of a gallic acid derivative having a structure represented by Formula 1 and a molecular formulae CHO. This invention also provides a novel process for preparation of said molecule from a naturally occurring compound and testing it for growth regulating activity using Bacopa test system developed at CIMAP (Khanuja et al., 2001) 

Gallic acid derivative and process of preparing the same

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Uttar Pradesh, India

Ankur Garg