Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Anke Mayer-bartschmid

Frank Wunder

Beatrix Stelte-Ludwig

Simone Greven

Tobias Marquardt

Christoph Mahlert

Jan Tebbe

Ernst Weber

Thomas Mondritzki

Damian Brockschnieder

Frank Dittmer

Lars Linden

Ricarda Finnern

Jörg Willuda

Axel Harrenga

Ilka Mathar

Andreas Wilmen

Lucas Hudson Hofmeister

Stuart Walsh

Marcel Geertz

Claudia Noack

Hannah Jörissen

Gabriele Leder

Juergen Franz

Yong-Jiang Cao

The present invention relates to an antibody or a fragment thereof comprising at least one heterologous amino acid sequence incorporated within at least one CDR region of said antibody or fragment thereof, wherein said at least one heterologous amino acid sequence comprises an N-terminal linker sequence (Nils), an Atrial Natriuretic Peptide (ANP) and a C-terminal linker sequence (Ctls). Optionally, at least a portion of said at least one CDR region is replaced by said at least one heterologous amino acid sequence incorporated therein. The present invention further relates to such antibody or fragment thereof for use in a method for treatment, a composition comprising such antibody or fragment thereof, a nucleic acid or a mixture of nucleic acids encoding such antibody or fragment thereof, a host cell comprising such nucleic acid or such mixture of nucleic acids and to a process for producing such antibody or fragment thereof.

Atrial natriuretic peptide engrafted antibodies

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Wülfrath, Germany

Anke Mayer-bartschmid