Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Pepticom Ltd.

Anke Burger-Kentischer

Herwig Brunner

Arnold Gillner

Steffen Rupp

Immanuel Lerner

Amit Michaeli

Georg Geiger

Heike Walles

Benjamin Greiner

Ina Hogk

Doris Finkelmeier

Angela Mattes

Maria Zatsepin

Michaela Kaufmann

Amriam Goldblum

Martin Wehner

Nadine Nottrodt

Dominik Riester

Monika Bach

Eva Brauchle

Katja Schenke-layland

Andreas Pippow

Phuong-Ha Nguyen

Katharina Hofer-schmitz

Heike Prof Walles

A group of peptides is provided which activate or inhibit toll-like receptor 4 (TLR4) and may be used to modulate inflammatory signaling and host defense pathways. The peptides were derived in silico and tested in vitro in cell cultures. These peptides may be used in the preparation of immunomodulatory compositions such as vaccine adjuvants and in pharmaceutical compositions for immunomodulation of the innate immune system such as vaccine adjuvants. The peptides may also be used in the preparation of TLR4 activators, TLR4 inhibitors and MD2 labels, e.g., for research purposes.

Peptide agonists and antagonists of TLR4 activation

A method of preventing or treating a disease characterized by an excessive immune response in a subject in need thereof is provided. The method includes administering to the subject a composition including an active component, wherein the active component is a first compound, a second compound, a third compound, a pharmaceutically acceptable salt thereof, a solvate thereof, or a combination thereof, wherein the first, second, and third compounds include: respectively.

Toll-like receptor 9 antagonists

The invention relates to a competitive immunoassay test system as well as a method to simply and rapidly detect pyrogens contained in a sample by means of the pyrogen binding domain of pattern recognition receptors. The test system comprises an assay carrier having at least one immobilized pyrogen binding domain of a pattern recognition receptor with a labeled, displaceable ligand, wherein the displacement of the ligand is indicated by a pyrogen contained in the sample by a color reaction of the labeling. The assay carrier preferably also has at least one immobilized ligand capture protein, which binds the displaced ligand and thereby initiates a color reaction of the labeling.

Competitive immunoassay test system for detecting a pyrogen

The invention relates to a multi-layered biological in vitro tissue containing: dermis layer, containing a collagen biomatrix with fibroblasts embedded therein and epidermis layer, containing epithelial cells. It is provided that latently virally infected neuronal cells are integrated at least into the dermis layer.

In vitro test system for viral infections

Growing community of inventors

Stuttgart, Germany

Anke Burger-Kentischer