Virginia Commonwealth University

Anjan K Pradhan

Paul B Fisher

Devanand Sarkar

Swadesh K Das

Mitchell E Menezes

Luni Emdad

Praveen Bhoopathi

Xiang-yang Wang

In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.

MDA-7/IL-24 secretory variants and methods of use

Growing community of inventors

Richmond, VA, United States of America

Anjan K Pradhan