Baylor University

Anjan Ghatak

Kevin G Pinney

Zhi Chen

James Michael Dorsey

Vani P Mocharla

Charles M Garner

A diverse set of tubulin binding ligands have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl&mdash;aryl, pseudo pi stacking distances appropriate for molecular recognition of tubulin. In phenolic or amino form, these ligands may be further functionalized to prepare phosphate esters, phosphate salts, and phosphoramidates capable of demonstrating selective targeting and destruction of tumor cell vasculature.

Growing community of inventors

Waco, TX, United States of America

Anjan Ghatak