Akzo Nobel N.v.

Anja Wiersma

Dirk Leysen

Jaap Van Der Louw

J Van Der Louw

D Leysen

R G J M Hanssen

(Androst-5-en-17beta -yl)alkyl sulfoxides and sulfones and their use for control of fertility

The invention relates to 22R-hydroxycholesta-8,14-diene derivatives having general formula (I) wherein R is OR, OS0 H or &boxH;NOR; with R being H, (C )alkyl or (C )acyl; each of R and R is independently hydrogen or (C )alkyl; R is hydrogen, (C )alkyl or (C )acyl; R is hydrogen; or R designates, together with R , an additional bond between the carbon atoms at which R and R are placed; R is hydrogen, hydroxy or halogen; or R designates, together with R , an additional bond between the carbon atoms at which R and R are placed; each of R and R is independently hydrogen or (C )alkyl, optionally substituted with OH, (C )alkoxy, or halogen; or a pharmaceutically acceptable salt thereof. The compounds of the invention have meiosis inhibiting activity and can be used for the control of fertility.

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HE Elst, Netherlands

Anja Wiersma