Merck Patent Gmbh

Anja-Nadine Knuettel

Dieter Lubda

Mengyao Zheng

Nicole Di Gallo

Alessandro Elia

An extrudable polyvinyl alcohol (PVA) powder with improved flowability containing particles of PVA, which has been cryo-milled, and which has dparticle sizes in the range of 45 to 1400 &#x3bc;m; or which has a particle size distribution of d=20&#xb1;10 &#x3bc;m, d=30&#xb1;10 &#x3bc;m, d=70&#xb1;10 &#x3bc;m, d=200&#xb1;30 &#x3bc;m, and d=300&#xb1;30 &#x3bc;m; and a powdery composition for the preparation of pharmaceutical formulations which contains the polyvinyl alcohol homogeneously mixed with at least one active pharmaceutical ingredient (API); and a process for producing a solid pharmaceutical dosage form by extruding or forming a homogeneous melt of a mixture of ingredients containing the powdered polyvinyl alcohol and at least one active pharmaceutical ingredient (API), and forming a powder or a molded form.

Particle size and distribution of polymer for melt extrusion application

The present invention relates to the use of an amino sugar as plasticizer in formulations comprising a polymer as carrier for active ingredients, in particular for compositions which are intensively mixed by treatment in a melt extrusion and then formulated by suitable post-treatment.

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Mannheim, Germany

Anja-Nadine Knuettel