Scil Proteins Gmbh

Navigo Proteins Gmbh

Anja Kunert

Erik Fiedler

Markus Fiedler

Arnd Steuernagel

Manja Gloser

Joerg Nerkamp

Thomas Goettler

Ilka Haenssgen

Jörg Narkamp

Thomas Göttler

Thomas Gottler

Jorg Nerkamp

Ilka Haenßgen

Jörg Nerkamp

The present invention refers to novel hetero-multimeric proteins obtained from modified ubiquitin capable of binding the extradomain B of fibronectin (ED-B) with high affinity. Furthermore, the invention refers to fusion proteins comprising said recombinant protein fused to a pharmaceutically and/or diagnostically active component. The invention is further directed to the use of said proteins in medical treatment methods.

Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin

The present invention refers to a method for identifying hetero-multimeric ubiquitins with binding capability to a ligand. Furthermore, the invention provides DNA libraries encoding for a population of said hetero-multimeric ubiquitins as well as protein libraries obtained by expression of said DNA libraries, cells and phages containing said DNA or proteins, polynucleotides encoding for said fusion proteins and vectors comprising said polynucleotides. Further new binding proteins based on hetero-multimeric ubiquitin being able to bind specifically with high affinity to selected ligands are provided.

Method for identifying hetero-multimeric modified ubiquitin proteins with binding capability to ligands

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Halle/Saale, Germany

Anja Kunert