Spinchip Diagnostics As

Anja Gulliksen

Stig Morten Borch

Torgeir Hamsund

Jostein Geir Holtlund

The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d&#x3e;mand m; and separating the liquid medium and the beads comprising the quantifiable bead complexes.

Analytical method

A method for transferring beads in a fluidic chip having an internal fluid circuit through which various reactants, including beads, may be moved by use of centrifugal force includes providing beads having a density equal to, or lower than, m1 in a section of the fluid circuit, where the section includes at least a first outlet. The method includes providing a first liquid medium having a density d2 to the section, such that d2&#x3e;m1, and applying a centrifugal force such that the beads migrate in an opposite direction of the centrifugal force.

Method of transferring beads

The present invention provides a method of separating beads in a fluidic chip comprising an internal fluid circuit through which various reactants, in which at least one of the reactants are beads, may be moved by use of centrifugal force, the method comprises the steps of: providing at least a first set of beads () having a density mand a second set of beads () having a density min a section () of the fluid circuit, the section comprising at least a first outlet (); providing a first liquid medium in the section, the liquid medium having a density d, such that m&#x3c;d&#x3c;m; and applying a first centrifugal force (G) such that the first set of beads () and the second set of beads () migrates in opposite directions within the section.

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Oslo, Norway

Anja Gulliksen