Brown University

Rhode Island Hospital

Anita Shukla

Christina Bailey-Hytholt

Shashank Shukla

Eleftherios Mylonakis

Anubhav Tripathi

Dahlia Alkekhia

Hannah Safford

Sarah Cowles

Beth Fuchs

Eli Silvert

Hanyang Liu

Noel Vera-Gonzalez

The invention provides a lipid bilayer mimicking the lipid composition of the placenta. The lipid composition provides an in vitro placenta model using the lipid composition of the placental cell membrane.

Placental lipid bilayer for cell-free molecular interaction studies

The invention provides a chromogenic β-lactam molecule that retains its diagnostic color change response when modified for conjugation to another molecule.

Chromogenic beta-lactamase substrate

The invention provides an auranofin-releasing antibacterial and antibiofilm polyurethane (PU) catheter coating. Auranofin is an antirheumatic drug with recently identified antimicrobial properties.

Auranofin-releasing antibacterial and antibiofilm polyurethane intravascular catheter coatings

The invention provides functionalized antifungal-loaded liposomal formulations targeting, which minimize damage to healthy human cells, limit antimicrobial exposure, and reduce the development of antifungal resistance.

Antifungal nanoparticles for targeted treatment of fungal infections

A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion concentration in the gel material may be altered to obtain the desired gel strength. The hydrogel formulation is layered directly upon a skin area such as burnt skin. The hydrogel formulation includes a dosage of free antibiotic, such as the antibiotic is preferably vancomycin, for rapid release. The hydrogel formulation also includes microparticles and/or nanoparticles such as activated carbon powder that has adsorbed additional antibiotic. The particles are used to aid in attaining a timely or sustained release of the antibiotic drug.

Growing community of inventors

Providence, RI, United States of America

Anita Shukla