Gilead Sciences, Inc.

Geron Corporation

Asterias Biotherapeutics, Inc.

Anita Reddy

Jane S Lebkowski

Feng Jin

Anish Sen Majumdar

Julie A Di Paolo

Michael J Hawkins

Suyi Tseng

Kevin Nishimoto

Jing Hu

Flordeliza Melchor-Khan

Christopher O'Sullivan

The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same and kits comprising the same.

Differentiation of primate pluripotent stem cells to hematopoietic lineage cells

Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma.

Methods for treating cancers

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San Ramon, CA, United States of America

Anita Reddy