Biothera Inc.

Anissa S H Chan

Nandita Bose

Keith B Gorden

William J Grossman

Steven M Leonardo

Michael E Danielson

John P Vasilakos

Jeremy Graff

Xiaohong Qiu

Mary A Antonysamy

Nadine Ottoson

Takashi Kangas

Kathryn A Fraser

Adria Bykowski Jonas

Ross Fulton

The invention generally relates to soluble beta-glucan compositions and method of using such compositions. In one aspect, an adjuvant for a pharmaceutical composition is described which includes a soluble beta-glucan and a TLR agonist, each in an amount that, in combination with the other, is effective to increase a subject's immune response to an antigen. In another aspect, compositions that generally include an antigen component, a soluble beta-glucan component, and a TLR agonist component and a method that generally includes administering to a subject a composition that comprises a soluble beta-glucan and a TLR agonist, each in an amount that, in combination with the other, is effective to increase a subject's immune response to an antigen, are described.

Compositions including beta-glucans and method of use

The present invention relates to the combination of soluble &#x3b2;-glucan and anti-cancer agents that affect the tumor microenvironment. Soluble &#x3b2;-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-cancer agents.

Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment

Described herein are compositions that include isolated opsonized soluble &#x3b2;-glucan, methods of making those compositions and methods of using those compositions.

Opsonized &#x3b2;-glucan preparations and methods

Described herein are beta-glucan compounds, compositions, and methods. Generally, the methods exploit the observation that beta-glucan compounds can bind to B cells. Thus, the methods generally include administering a beta-glucan compound to a subject in an amount effective for the beta-glucan compound to bind to a B cell and modulate at least one biological function of the B cell.

Beta-glucan compounds, compositions, and methods

Compositions including &#x3b2;-glucans and methods of use

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Arden Hills, MN, United States of America

Anissa S H Chan