Geron Corporation

Stempeutics Research Pvt. Ltd.

The University of Edinburgh

The University of Western Ontario

Asterias Biotherapeutics, Inc.

Anish Sen Majumdar

Pawan Kumar Gupta

Jane S Lebkowski

Anita Reddy

Jyothi Prasanna

Satish Totey

Raviraja Neelavar Seetharam

Umesh Baikunje Golithadka

Prasanna Kumar Kemburu

Suyi Tseng

Kevin Nishimoto

Rakhi Pal

Mickie Bhatia

David Colin Hay

Joaquin Madrenas

Wei Cui

Debiao Zhao

Iris A Ferber

Melinda Au

JianJie Jiang

Mathiyazhagan Rengasamy

Charan Thej

Sudha Balasubramanian

Anoop Chullikana House

The present invention discloses a method of isolation, pooling and further culturing of Mesenchymal Stem cells (MSC) for clinical application. Present invention also discloses the method of establishing Master Cell bank, followed by Working Cell Bank from which the final therapeutic composition referred to as Investigational Product/Investigational Medicinal Product comprising of allogenic bone marrow-derived MSC is formulated for clinical applications.

Allogeneic mesenchymal stem cell compositions and methods thereof

The present disclosure relates to composition comprising pooled and expanded allogeneic mesenchymal Stromal cells (MSCs) and a method for management of Ischemia using the composition thereof. In particular, the disclosure relates to bone marrow derived pooled and expanded allogeneic MSC compositions with effective dosage ranges and modes/route of administration for effective management of Ischemia. The disclosure also relates to the use of conditioned medium rich in bioactive factors in combination with the cell composition for managing ischemic conditions.

Management of ischemia using pooled mesenchymal stromal cell composition

The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same and kits comprising the same.

Differentiation of primate pluripotent stem cells to hematopoietic lineage cells

Methods of preparing mesenchymal stem cells, compositions and kit thereof

Methods for differentiating human pluripotent stem cells into islet-like cells are provided. In certain embodiments, the methods utilize sequential culturing of the human pluripotent stem cells with certain factors to produce islet-like cells. In certain embodiments, the population of cells produced by the methods is further enriched for islet-like cells.

Differentiation and enrichment of islet-like cells from human pluripotent stem cells

Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cells. In certain embodiments, the population of cells produced by the methods is further enriched for hepatocyte-lineage cells.

Differentiation of primate pluripotent cells to hepatocyte-lineage cells

This disclosure provides a system for minimizing the alloreactivity of tissue transplants. The patient is administered with undifferentiated embryonic stem cells or early progenitor cells. This induces a state of inflammatory quiescence or immune unresponsiveness, which in turn enhances engraftment of cells derived from the same stem cell line given for purposes of regenerative medicine.

Using undifferentiated embryonic stem cells to control the immune system

Growing community of inventors

Mumbai, India

Anish Sen Majumdar