Akamara Therapeutics, Inc.

Invictus Oncology Pvt. Ltd.

Ankara Therapeutics, Inc.

Aniruddha Sengupta

Shiladitya Sengupta

Monideepa Roy

Arindam Sarkar

Pradip Dutta

Sk Samad Hossain

Aasif Ansari

Anubhab Mukherjee

Samad Hossain

Sanghamitra Mylavarapu

Swadhin K Mandal

Pradip Kumar Dutta

The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

Lipid-based platinum compounds and nanoparticles

The present disclosure relates generally to supramolecular combinatorial therapeutics, compositions comprising same, and uses thereof. In particular, the present disclosure provides hydrophobic taxane-lipid covalent conjugates which create supramolecular assembly, for example, within lipid bilayer, providing an extra stabilization resulting in increased intratumoral concentration and hence increased efficacy. The present disclosure also provides supramolecular combinatorial therapeutics, wherein a taxane-lipid conjugate is combined with one or more of a platinum compound, a kinase inhibitor, and an immunoregulator, each of which is optionally conjugated with a lipid.

Supramolecular combinatorial therapeutics

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New Delhi, India

Aniruddha Sengupta