Johnson Matthey Public Limited Company

Aniruddh Singh

Mahmoud Mirmehrabi

Saroop Matharu

Brian Heinrich

An improved method for the preparation of the low ABUK oxymorphone hydrochloride is provided. The oxymorphone hydrochloride is produced by hydrogenating a starting material comprising oxymorphone base and 14-hydroxymorphinone in a mixture comprising an alcohol, water and an acid, removing some of the water and adding more alcohol to the mixture.

Process of preparing low ABUK oxymorphone hydrochloride

The present disclosure is directed to crystalline forms of oxymorphone hydrochloride and compositions comprising any of the crystalline forms of oxymorphone hydrochloride. Also provided are processes for the preparation of crystalline forms of oxymorphone hydrochloride.

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Acton, MA, United States of America

Aniruddh Singh