Biocon Limited

Biocon India Limited

Anindya Sircar

Shrikumar Suryanarayan

Anand Khedkar

Shreehas Pradeep Tambe

Pampapathy Subramaniyam

Ramakrishnan Melarkode

Madhavan Sridharan

Sambasivam Ganesh

Poornaprajna Acharya

Melarkode Ramkrishna

Madhay Kulkarni

Ganesh Samvasivam

Konayakanahalli Nanjunda Swamy Anand

The present invention provides an improved method for the manufacture of Cyclosporin A is disclosed. Cyclosporin A is produced by solid state fermentation ofin a bioreactor under optimal fermentation parameters. The product is extracted and further purified by treating with alum and subsequent chromatographic procedures to get pharmaceutical acceptable purity.

Manufacture and purification of cyclosporin A

The present invention provides an improved method for the manufacture of Mycophenolic acid by solid substrate fermentation of, in a contained bioreactor under optimal fermentation parameters with its subsequent purification steps.

Manufacture and purification of mycophenolic acid

Methods for the manufacture of Mycophenolate are disclosed. Mycophenblate mofetil is biochemically synthesized using Mycophenolic Acid and 2-morpholino ethanol with the help of an enzyme. Mycophenolate mofetil is also chemically synthesized non-catalytically by refluxing mycophenolic acid with 2-morpholino ethanol in the absence of a third solvent or a catalyst.

Methods of producing esters of mycophenolate

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Karnataka, India

Anindya Sircar