Albany Molecular Research, Inc.

Animesh Ghosh

Peter Guzzo

Alan John Henderson

Matthew L Isherwood

He Zhao

Kassoum Nacro

Chong Yew Lee

Kai Xiang

The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.

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The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT) modulators, pharmaceutical compositions including these compounds, and methods of preparation and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, and schizophrenia. The subject compounds have the structure of formula (I) with the substituents being described herein.

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Singapore, Singapore

Animesh Ghosh